Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Magnesium tocolysis: serum levels versus success.

C Madden1, J Owen, J C Hauth

  • 1Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.

American Journal of Obstetrics and Gynecology
|May 1, 1990
PubMed
Summary

Maternal serum magnesium levels do not reliably predict tocolytic success in preterm labor. This study found no significant relationship between magnesium concentrations and successful treatment outcomes at 48 hours or 7 days.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A scoping review of dental practitioners' perspectives on perceived barriers and facilitators to preventive oral health care in general dental practice.

BMC oral health·2024
Same author

Impacts of metal mining on river systems: a global assessment.

Science (New York, N.Y.)·2023
Same author

Do routine outcome monitoring measures tell the same story? Evaluating outcome trajectories and clinical outcomes for the outcome rating scale and outcome questionnaire - 45.

Psychotherapy research : journal of the Society for Psychotherapy Research·2023
Same author

Bayesian emulation and history matching of JUNE.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2022
Same author

The use of portable XRF as a forensic geoscience non-destructive trace evidence tool for environmental and criminal investigations.

Forensic science international·2022
Same author

Reflection on the proposed changes to dose quantities-an industrial perspective.

Journal of radiological protection : official journal of the Society for Radiological Protection·2021

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Maternal-Fetal Medicine

Background:

  • The efficacy of magnesium sulfate as a tocolytic agent for preterm labor is widely used.
  • However, the precise relationship between maternal serum magnesium levels and tocolytic success remains unclear.
  • Establishing clear therapeutic targets for magnesium levels is crucial for optimizing treatment.

Purpose of the Study:

  • To investigate the association between maternal serum magnesium levels and the success of tocolysis in patients experiencing preterm labor.
  • To determine if specific serum magnesium concentration thresholds correlate with improved tocolytic outcomes.

Main Methods:

  • A retrospective analysis was conducted on 101 episodes of preterm labor treated with magnesium sulfate.

Related Experiment Videos

  • Maternal serum magnesium levels (initial, average, maximum) were compared with tocolytic success rates at 48 hours and 7 days.
  • Statistical analyses, including logistic regression, were employed to assess the relationship.

    • Main Results:

    • No significant difference in tocolytic success rates was observed between serum magnesium levels below 6 mg/dl and those at or above 6 mg/dl.
    • Similar analyses around a 5 mg/dl threshold also showed no significant relationship.
    • Mean serum magnesium levels did not differ statistically between patients with successful and failed tocolysis.

    Conclusions:

    • Maternal serum magnesium levels alone are not a reliable indicator of tocolytic success in managing preterm labor.
    • Therapeutic monitoring of serum magnesium levels should not be the sole endpoint for evaluating the effectiveness of magnesium sulfate therapy.
    • Further research may be needed to identify optimal clinical parameters for magnesium sulfate tocolysis.