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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Hormones That Influence Osteoblasts and/or Maintain the Matrix
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
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Related Experiment Video

Updated: May 14, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

ATP and arterial calcification.

Richard S Fish1, Enriko Klootwijk, Frederick W K Tam

  • 1UCL Centre for Nephrology, UCL Medical School, London, UK. rsfish@doctors.org.uk

European Journal of Clinical Investigation
|February 13, 2013
PubMed
Summary
This summary is machine-generated.

Arterial calcification (AC) treatment is lacking. Emerging research highlights the purinergic system, involving adenosine triphosphate (ATP), as a potential therapeutic target for AC. Further investigation is needed.

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Area of Science:

  • Biomedical Science
  • Cardiovascular Research
  • Biochemistry

Background:

  • Arterial calcification (AC) is a significant health concern linked to high morbidity and reduced survival.
  • Currently, no effective treatments exist for arterial calcification.
  • The purinergic system, including adenosine triphosphate (ATP), is increasingly recognized for its role in AC development.

Purpose of the Study:

  • To systematically review and analyze the current literature on the purinergic system's relevance to arterial calcification.
  • To emphasize the enzymes involved in ATP metabolism and their function in regulating arterial mineralization.
  • To identify controversies and suggest future research directions.

Main Methods:

  • Systematic literature review.
  • Analysis of current research on the purinergic system and arterial calcification.
  • Focus on ATP metabolism enzymes and their role in arterial mineralization.

Main Results:

  • The purinergic system plays a significant role in the pathogenesis of arterial calcification.
  • Enzymes in ATP metabolism are crucial for balancing arterial mineralization.
  • Current knowledge suggests potential therapeutic targets within the purinergic system.

Conclusions:

  • The involvement of ATP and the purinergic system in AC is becoming clearer.
  • Further research is essential to fully understand these roles.
  • Components of the purinergic system offer promising avenues for novel AC treatments.