Related Experiment Video
Updated: May 14, 2026
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies
Kevin S Martin1, Cristian Soldi, Kellan N Candee
1Department of Chemistry, University of California, Davis, CA 95616, USA ; Comparative Pathology Graduate Group, University of California, Davis, CA 95616, USA.
Abstract:
A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a "one-bead, one-compound" combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy.
