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Updated: May 14, 2026

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Use of a Rat Model to Study Ventral Abdominal Hernia Repair
Published on: October 2, 2017
Onlay ventral hernia repairs using porcine non-cross-linked dermal biologic mesh
1Department of Surgery, Keck School of Medicine, The University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA, 90033, USA.
Hernia : the Journal of Hernias and Abdominal Wall Surgery
|February 13, 2013
Summary
Porcine biologic mesh onlay offers excellent short-term outcomes for complex ventral hernia repair, especially in high-risk patients. This method showed no mesh removal or recurrence in primary fascial closure cases.
Area of Science:
- Surgical innovation
- Hernia repair techniques
- Biomaterials in surgery
Background:
- Ventral hernias are prevalent, with mesh repair reducing recurrence.
- Synthetic mesh carries infection risks; biologic mesh is an alternative.
- Onlay mesh placement is explored as an alternative to sublay for complex ventral hernias.
Purpose of the Study:
- To evaluate the outcomes of complex ventral hernia repair.
- To assess the efficacy of porcine non-cross-linked biologic mesh in an onlay position.
Main Methods:
- Retrospective review of ventral hernia repairs using biologic mesh (Jan 2009-Mar 2012).
- Open repair with primary fascial closure, component separation, and porcine biologic mesh onlay.
- Analysis of patient demographics, hernia grade, surgical approach, complications, and recurrence.
Main Results:
- 22 patients underwent repair; most were male with high-grade hernias post-cancer surgery.
- 16 patients (73%) had external oblique component separation; median hospital stay was 7 days.
- Two superficial infections occurred (no mesh removal); 6 patients (27%) developed seroma requiring drainage. No recurrence with primary closure.
Conclusions:
- Porcine non-cross-linked biologic mesh onlay demonstrates excellent short-term results for high-risk ventral hernia patients.
- No mesh removal was necessary, and primary fascial closure cases showed no recurrence.
- Biologic mesh bridging is not recommended for long-term abdominal wall reconstruction.

