Bioinspired All-in-One Wound Dressing: Integrating Photothermal-Enhanced Drainage and Strain-Sensing Monitoring for...

Area of Science:

• Biomaterials Science
• Wound Healing
• Nanotechnology

Background:

• Chronic wound management is hindered by poor liquid drainage and persistent bacterial infections.
• Existing treatments often lack integrated functionalities for comprehensive wound care.

Purpose of the Study:

• To design and evaluate a biomimetic asymmetric bilayer electrospun nanofiber membrane for chronic wound management.
• To integrate one-way drainage, photothermal evaporation, antibacterial properties, and real-time monitoring into a single intelligent dressing.

Main Methods:

• Fabrication of an asymmetric bilayer membrane using hydrophilic (tannic acid/iron and silver nanowires modified polyurethane) and hydrophobic polyurethane.
• Utilizing the wetting gradient for rapid liquid pumping and photothermal properties for exudate evaporation and antibacterial action.
• Incorporating silver nanowires for conductivity to enable strain sensing and movement monitoring.

Main Results:

• The membrane demonstrated efficient one-way liquid drainage within 10 seconds.
• Photothermal properties facilitated rapid exudate evaporation and antibacterial effects.
• Achieved a 94.6% wound healing rate in animal experiments.
• The dressing exhibited excellent sensing capabilities for real-time monitoring.

Conclusions:

• The developed intelligent dressing effectively integrates multiple functionalities for advanced chronic wound management.
• The biomimetic design offers a promising solution for improving wound healing rates and patient monitoring.
• This technology holds significant potential for clinical application in treating complex wounds.