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Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia
David Y Johnson1, Diana L Dunkelberger, Maya Henry
1Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143-1207, USA.
Objective:
To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.
Design:
Case report.
Setting:
Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.
Patient:
Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.
Results:
Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.
Conclusions:
These findings expand the differential of primary progressive aphasia to include prion disease.
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