Related Experiment Video
Updated: May 14, 2026
06:55
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Pregnancy outcomes among patients with vasculitis
Megan E B Clowse1, Rachel L Richeson, Carl Pieper
1Duke University Medical Center, Durham, NC 27710, USA. megan.clowse@duke.edu
Arthritis Care & Research
|February 13, 2013
Summary
Pregnancy after a vasculitis diagnosis is linked to increased pregnancy loss and preterm birth rates in women. Vasculitis activity typically did not worsen during pregnancy for most patients.
Area of Science:
- Rheumatology
- Obstetrics & Gynecology
- Clinical Research
Background:
- Pregnancy outcomes in patients with vasculitis are not well-documented.
- Understanding these outcomes is crucial for patient care and counseling.
Purpose of the Study:
- To assess pregnancy outcomes in individuals diagnosed with vasculitis.
- To investigate the impact of disease diagnosis timing on pregnancy outcomes.
Main Methods:
- An anonymous online survey was distributed to patients in the Vasculitis Clinical Research Consortium Patient Contact Registry.
- Survey data included pregnancy outcomes, timing of conception relative to vasculitis diagnosis, and medication use.
Main Results:
- Women conceiving after a vasculitis diagnosis had higher rates of pregnancy loss (33.8%) and preterm birth (23.3%) compared to those conceiving before diagnosis (22.4% and 11.4%, respectively).
- Most women (82%) did not report worsening vasculitis during pregnancy, but increased activity correlated with preterm delivery.
- Medication exposure (cyclophosphamide, prednisone) did not show a significant impact on outcomes due to small sample sizes.
Conclusions:
- Conceiving after a vasculitis diagnosis is associated with poorer pregnancy outcomes, including increased pregnancy loss.
- Vasculitis generally remained stable during pregnancy for the majority of patients studied.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:19Mitral Valve Prolapse III: Nursing Management
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
01:26Varicose Veins II: Diagnostic Studies and Interprofessional Care
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...