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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
Genomic responses in mouse models poorly mimic human inflammatory diseases.
Junhee Seok1, H Shaw Warren, Alex G Cuenca
1Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94305, USA.
Summary
Mouse models poorly mimic human inflammatory diseases, showing random gene response correlation. Future research should prioritize complex human conditions over animal models for better translational medicine outcomes.
Area of Science:
- Biomedical Research
- Translational Medicine
- Genomics
Background:
- Mouse models are crucial for understanding disease and testing therapies.
- Current mouse models for inflammatory diseases lack systematic evaluation for human mimicry.
Purpose of the Study:
- To assess the correlation between genomic responses in mouse models and human inflammatory diseases.
- To evaluate the reliability of mouse models in preclinical research.
Main Methods:
- Comparative genomic analysis of human and mouse responses to acute inflammatory stress.
- Statistical assessment of gene ortholog expression correlation (R-squared values).
Main Results:
- Human inflammatory responses to diverse stresses show high genomic similarity.
- Mouse models exhibit poor correlation with human inflammatory disease genomic profiles (R-squared 0.0-0.1).
- Murine ortholog gene responses poorly matched human counterparts.
Conclusions:
- Current mouse models inadequately replicate human inflammatory disease genetics.
- Improvements in animal models are needed.
- Translational research should increase focus on human conditions rather than mouse models.
