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Updated: May 14, 2026
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Giant renal oncocytoma.
Nebojsa Stojanović1, Ivan Ignjatovic, Milos Kostov
1Department of Urology, Military Hospital Nis, Nis, Serbia. nesha.stojanovic@gmail.com
Vojnosanitetski Pregled
|February 14, 2013
Summary
Giant renal oncocytomas are rare, benign kidney tumors often found incidentally. Definitive diagnosis requires histopathology, as distinguishing them from kidney cancer pre-operatively is challenging.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Renal oncocytoma is a benign tumor originating from distal renal tubule epithelial cells.
- These tumors are frequently asymptomatic and incidentally discovered.
- Distinguishing renal oncocytoma from renal cell carcinoma pre-operatively is difficult.
Observation:
- A case of a giant renal oncocytoma (16 x 14 cm) in a 64-year-old male is presented.
- The patient was asymptomatic and the tumor was pre-operatively diagnosed as a malignant kidney tumor.
- Radical nephrectomy was performed, revealing a tumor with a central hyaline scar.
Findings:
- Microscopic examination showed uniform polygonal cells with eosinophilic cytoplasm.
- Immunohistochemistry revealed tumor cell reactivity to CK AE1/AE3 and CD 117.
- Tumor cells were negative for CK 7, RCC marker, and Vimentin.
Implications:
- Giant renal oncocytomas are rare and have a benign clinical course.
- Clinical differentiation from malignant kidney tumors is not feasible.
- Histopathological examination with immunohistochemistry is essential for definitive diagnosis.
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