Related Experiment Video
Updated: May 14, 2026

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
Published on: April 16, 2021
Heart valve disease
1Department of Internal medicine, University of Michigan Health System, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5644, USA. adamhelm@med.umich.edu
Abstract:
Heart valve disease is often characterized by a prolonged asymptomatic period that lasts for years and presents primary care physicians with an opportunity to detect disease before irreversible heart failure or other cardiac complications develop. Acute valvular disease can masquerade as respiratory illness or present with nonspecific systemic symptoms, and an astute examination by a primary care physician can direct appropriate care. Therefore, an understanding of the common pathologies and presentations of valvular heart disease is critical. This review focuses on the 2 most common valve lesions, aortic stenosis and mitral regurgitation, and provides an overview of other valve disease topics.
Related Concept Videos
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Stenosis I: Introduction
Rheumatic Heart Disease I: Introduction
Mitral Regurgitation I: Introduction
Mitral Valve Prolapse I: Introduction
Mitral Stenosis IV: Nursing Management

