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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

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Related Experiment Video

Updated: May 14, 2026

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

Nano bioresearch approach by microtechnology.

Dominique Collard1, Soo Hyeon Kim, Toshihisa Osaki

  • 1LIMMS/CNRS-IIS, UMI 2820, Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8505, Japan. collard@iis.u-tokyo.ac.jp

Drug Discovery Today
|February 14, 2013
PubMed
Summary
This summary is machine-generated.

Micro and nanotechnologies enable new miniature devices for biological assays. These advancements support progress in basic science, drug development, and translational research by enabling high-throughput analysis of biological molecules.

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • There is a growing need for efficient methods to detect biological molecules and their interactions within living organisms.
  • Advancements in micro and nanotechnologies over two decades have matured, enabling novel miniature devices.
  • These technologies facilitate compartmentalized bioassays for various applications.

Purpose of the Study:

  • To review emerging micro and nanotechnologies for biological assays.
  • To highlight examples of miniature devices and their applications in biological research.
  • To assess the potential of these technologies in translational research and drug discovery.

Main Methods:

  • Review of micro and nanotechnological platforms for bioassays.
  • Examples include electro-active microwells for single-cell analysis.
  • Other examples: nanofluidics for DNA separation, droplet-based enzymatic reactions, and high-throughput membrane protein assays.

Main Results:

  • Demonstration of highly parallel single-cell analysis using electro-active microwells.
  • Showcasing cost-effective nanofluidic devices for DNA separation.
  • Presentation of 100pL droplet assays for parallel enzymatic reactions and high-throughput membrane protein analysis.

Conclusions:

  • Micro and nanotechnologies offer powerful tools for biological analysis.
  • These miniature devices are poised to significantly impact translational research.
  • The reviewed technologies hold promise for accelerating drug discovery and development.