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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Updated: May 14, 2026

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

Mesenchymal autologous stem cells.

Asdrubal Falavigna1, Jaderson Costa da Costa2

  • 1Department of Neurosurgery, Medical School of the University of Caxias do Sul, Caxias do Sul, Brazil.

World Neurosurgery
|February 14, 2013
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cell therapy shows promise for spinal cord injuries, but potential adverse effects like tumor modulation require careful consideration for clinical application.

Keywords:
Cell transplantationClinical translationsMesenchymal stem cellsNeuronal differentiationSpinal cord injury

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Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Cell Therapy

Background:

  • Cell-based therapies are emerging as a significant treatment strategy for spinal cord injuries.
  • Mesenchymal stem cells (MSCs) have demonstrated encouraging outcomes in preclinical and clinical studies for spinal cord injury treatment.
  • Concerns exist regarding the potential adverse effects of stem cell therapies, particularly their impact on tumor development.

Purpose of the Study:

  • To review the current literature on autologous mesenchymal stem cells for spinal cord injuries.
  • To discuss the clinical implications and potential benefits of this therapeutic approach.
  • To highlight the safety considerations, including tumor modulation risks.

Main Methods:

  • Literature survey of experimental and clinical studies.
  • Analysis of research on mesenchymal stem cell therapy for spinal cord injuries.
  • Review of reported adverse effects and clinical outcomes.

Main Results:

  • Mesenchymal stem cell therapy shows potential for treating spinal cord injuries.
  • Encouraging results have been observed in both experimental and clinical settings.
  • Reports indicate potential adverse effects, including tumor modulation, need further investigation.

Conclusions:

  • Autologous mesenchymal stem cells represent a promising therapeutic avenue for spinal cord injuries.
  • Careful evaluation of safety profiles, especially regarding oncogenic potential, is crucial for clinical translation.
  • Further research is needed to optimize efficacy and mitigate risks associated with MSC-based therapies.