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Updated: May 14, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Dose perturbations by electromagnetic transponders in the proton environment
Derek Dolney1, James McDonough, Neha Vapiwala
1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA. Derek.Dolney@uphs.upenn.edu
Abstract:
Surgically implanted electromagnetic transponders have been used in external beam radiotherapy for target localization and position monitoring in real time. The effect of transponders on proton therapy dose distributions has not been reported. A Monte Carlo implementation of the transponder geometry is validated against film measurements in a proton SOBP and subsequently used to generate dose distributions for transponders at different positions and orientations in the proton SOBP. The maximum dose deficit is extracted in each case. Dose shadows of up to 60% occur for transponders positioned very near the end of range of the Bragg peak. However, if transponders are positioned further than 5 mm from the end of range, and are not oriented parallel to the beam direction, then the dose deficit can be kept below 10%.
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