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Related Experiment Video

Updated: May 14, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

High-throughput hyperdimensional vertebrate phenotyping.

Carlos Pardo-Martin1, Amin Allalou, Jaime Medina

  • 1Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Nature Communications
|February 14, 2013
PubMed
Summary
This summary is machine-generated.

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High-throughput in vivo phenotyping rapidly screens entire vertebrates for complex biological responses. This new method captures hundreds of morphological features, enabling faster and more detailed analysis of gene mutations and drug effects.

Area of Science:

  • Developmental biology
  • Toxicology
  • High-throughput screening

Background:

  • Cell culture models fail to predict complex animal responses to genetic or molecular changes.
  • Traditional animal studies are slow and offer limited phenotypic readouts.
  • There is a need for faster, more comprehensive methods for in vivo analysis.

Purpose of the Study:

  • To develop a high-throughput method for rapid, detailed in vivo phenotyping of entire vertebrates.
  • To enable the simultaneous analysis of numerous morphological features and complex phenotypes.
  • To demonstrate the utility of this approach in toxicology and drug discovery.

Main Methods:

  • High-throughput optical projection tomography with micrometre resolution.
  • Development of a simple fluidic system for automated screening.

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Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
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Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

Published on: June 26, 2014

Related Experiment Videos

Last Updated: May 14, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
10:19

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

Published on: June 26, 2014

  • Hyperdimensional screening of semitransparent zebrafish larvae.
  • Clustering of quantitative phenotypic signatures for data analysis.

    • Main Results:

    • Hundreds of independent morphological features and complex phenotypes captured in 3D in tens of seconds.
    • Detection and classification of subtle alterations in multiple biological processes.
    • Analysis of teratogen effects on cartilage formation using 200 morphological measurements.
    • Identification of similarities and differences in teratogen mechanisms correlating with mammalian data.

    Conclusions:

    • Hyperdimensional in vivo phenotyping offers unprecedented speed and detail for analyzing complex biological responses.
    • The method facilitates the rapid assessment of genetic and molecular perturbations in whole organisms.
    • This approach has significant potential for accelerating drug discovery and toxicological assessments.