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Mouse Model of Pressure Ulcers After Spinal Cord Injury
Published on: March 9, 2019
Interleukin-17 expression in murine pressure ulcer tissues
Wei Cui1, Lei-Fang Yang, Wen-Hong Wei
1Departments of Special Medical Service, The Central Hospital of Xinxiang, Xinxiang, Henan 453600, P.R. China.
Experimental and Therapeutic Medicine
|February 14, 2013
Summary
Interleukin-17 (IL-17) levels were significantly elevated in a mouse model of pressure ulcers. This finding suggests a potential role for IL-17 in the development of pressure ulcers.
Area of Science:
- Biomedical Science
- Immunology
- Wound Healing Research
Background:
- Pressure ulcers are a significant clinical challenge, often leading to tissue damage and inflammation.
- The underlying molecular mechanisms of pressure ulcer formation require further elucidation.
Purpose of the Study:
- To investigate the expression of interleukin-17 (IL-17) in a mouse model of pressure ulcers.
- To determine the association between IL-17 and pressure ulcer development.
Main Methods:
- A mouse model of pressure ulcers was created using ischemia-reperfusion injury.
- Hematoxylin and eosin staining was used for histological analysis.
- Real-time PCR and Western blot assays quantified IL-17 mRNA and protein levels.
Main Results:
- Histological examination revealed inflammatory cell infiltration in pressure ulcer tissues.
- Both IL-17 mRNA and protein expression levels were significantly higher in the experimental group compared to the control group (P<0.05).
Conclusions:
- Elevated IL-17 expression is observed in pressure ulcer tissues.
- Interleukin-17 may play a role in the pathogenesis of pressure ulcers.
