[Fructosamine--a dynamic indicator of compensation in diabetes]

The serum fructosamine concentration was evaluated in 22 diabetics on admission to hospital and after intensified treatment with an insulin pump which was indicated on account of decompensation of diabetes. The drop of the mean glucose concentration in blood after 12 days of treatment correlated with the statistically significant drop of the serum fructose concentration (r = 0.69, p less than 0.001). Between the glucose and fructosamine serum concentration no relationship was observed, as long as the mean glucose concentration was calculated for a period shorter than the previous seven days. A highly significant correlation was observed between the rate of fructosamine decline and the mean blood sugar level (r = 0.94, p less than 0.001). From the dynamic changes ensues that when the mean blood sugar level declined by 1 mmol/l, the fructosamine level declined on average by 0.13 mmol/l. The results suggest a more rapid turnover of glycosylated proteins, as compared with data in the literature pertaining to non-glycosylated proteins.