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Preadolescent indomethacin-responsive headaches without autonomic symptoms
Kenneth Alexis Myers1, Kim A Smyth
1Pediatrics, Division of Neurology, University of Calgary, Calgary, AB, Canada.
Headache
|February 15, 2013
Summary
Preadolescent patients with severe, sudden headaches responded well to indomethacin. This suggests a potential new syndrome of indomethacin-responsive headache in children, even without typical autonomic symptoms.
Area of Science:
- Pediatric Neurology
- Pharmacology
Background:
- Preadolescent indomethacin-responsive headache is a rare condition with limited research.
- Understanding this entity is crucial for accurate diagnosis and treatment in young patients.
Observation:
- Two preadolescent children presented with frequent, severe, sudden-onset headaches.
- Headaches were paroxysmal, lasting seconds to minutes, with no associated autonomic or migrainous features.
- Extensive work-up excluded secondary causes for the debilitating headaches.
Findings:
- Both patients experienced dramatic clinical improvement with indomethacin treatment.
- This response suggests a specific headache syndrome responsive to indomethacin.
Implications:
- A distinct pediatric syndrome of indomethacin-responsive headache, potentially without autonomic symptoms, may exist.
- Further research is needed to establish optimal dosage and treatment duration for pediatric indomethacin-responsive headache.
- Indomethacin should be considered for severe paroxysmal headaches in children after ruling out secondary causes.
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