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Relation of angiographic thrombus burden with electrocardiographic grade III ischemia in patients with ST-segment

Mustafa Kurt1, Mehmet Fatih Karakas, Eyup Buyukkaya

  • 11Department of Cardiology, Mustafa Kemal University Medical School, Hatay, Turkey.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|February 15, 2013
PubMed

Insights

Electrocardiographic (ECG) grade III ischemia is a significant predictor of high thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). A history of coronary artery disease (CAD) also indicates higher thrombus burden.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Diagnostic Imaging

Background:

  • Acute ST-segment elevation myocardial infarction (STEMI) requires prompt reperfusion therapy.
  • Assessing thrombus burden is crucial for guiding treatment and predicting outcomes.
  • The relationship between ECG findings and angiographic thrombus burden needs further clarification.

Purpose of the Study:

  • To investigate the association between electrocardiographic (ECG) grade III ischemia and angiographic thrombus burden.
  • To identify predictors of high thrombus burden in STEMI patients undergoing primary percutaneous coronary intervention (pPCI).

Main Methods:

  • Analysis of baseline ECGs for grade III ischemia in 307 STEMI patients.
  • Assessment of angiographic thrombus burden using the Thrombolysis in Myocardial Infarction (TIMI) thrombus classification.
  • Statistical analysis to determine independent predictors of high thrombus burden.

Main Results:

  • High thrombus burden was observed in 65% of patients.
  • Grade III ischemia was significantly more prevalent in patients with high thrombus burden (25.1% vs 11.1%, P = .004).
  • ECG grade III ischemia (OR: 2.59, 95% CI: 1.24-5.39, P = .011) and a history of coronary artery disease (CAD) were independent predictors of high thrombus burden.

Conclusions:

  • ECG grade III ischemia is an independent predictor of coronary thrombus burden in STEMI patients.
  • A prior history of CAD is also an independent predictor of increased thrombus burden.
  • These findings can aid in risk stratification and treatment decisions for STEMI patients.
Abstract

Keywords:
ST-elevation myocardial infarctiongrade III ischemiathrombus burden

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