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Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic
1Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China.
Background:
To investigate the feasibility of postauricular hypodermic injection for treating inner ear disorders, we compared perilymph pharmacokinetics for postauricular versus intravenous injection, using magnetic resonance imaging, in an animal model.
Methods:
Twelve albino guinea pigs were divided randomly into two groups and administered gadopentetate dimeglumine via either a postauricular or an intravenous bolus injection. A 7.0 Tesla magnetic resonance imaging system was used to assess the signal intensities of gadolinium-enhanced images of the cochlea, as a biomarker for changes in gadopentetate dimeglumine concentration in the perilymph. Pharmacokinetic parameters were calculated based on these signal intensity values.
Results:
Guinea pigs receiving postauricular injection showed longer times to peak signal intensity, longer elimination half-life, longer mean residence time and a greater area under the signal-time curve (from pre-injection to the last time point) (p < 0.05).
Conclusion:
Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.
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