Related Experiment Video
Updated: May 14, 2026
Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review
Brad P Barnett1, James T Handa
1Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Background:
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated.
Objective:
To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD.
Methods:
A literature review.
Results:
The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis.
Conclusions:
Oxidative stress and complement dysregulation play a substantive role in the development of AMD.
