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Decrease recurrence rate of condylomata acuminata by photodynamic therapy combined with CO2 laser in mainland China:
Xiaoling Zhu1, Hongxiao Chen, Longfeng Cai
1Department of Pathology, Basic Medical Science College, Harbin Medical University, Harbin, China.
Background:
Condylomata acuminata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate.
Objectives:
To compare the recurrence rate of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser and CO2 laser alone for CA treatment in mainland China.
Methods:
In this meta-analysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALA-PDT combined with CO2 laser, and CO2 laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared.
Results:
The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (χ(2) = 271.98, p < 0.0001).
Conclusion:
ALA-PDT combined with CO2 laser was more effective in decreasing the recurrence rate of CA compared with CO2 laser alone. It might offer a wide clinical application for CA treatment.
