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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

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Related Experiment Video

Updated: May 14, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Systematic screening for active tuberculosis: rationale, definitions and key considerations.

K Lönnroth1, E Corbett, J Golub

  • 1Policy Strategy and Innovations, Stop TB Department, World Health Organization, Geneva, Switzerland. lonnrothk@who.int

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|February 15, 2013
PubMed
Summary
This summary is machine-generated.

Current tuberculosis (TB) detection efforts have plateaued, with many undetected cases remaining. The World Health Organization (WHO) is exploring new systematic screening strategies for active TB, including mass screening, to improve case detection rates.

Related Experiment Videos

Last Updated: May 14, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Area of Science:

  • Public Health
  • Infectious Disease Epidemiology
  • Global Health

Background:

  • Current interventions for early tuberculosis (TB) detection have reached saturation, leading to stagnated case detection trends.
  • Despite declining incidence in many regions, the rate of decline is insufficient to meet global targets.
  • A significant pool of undetected TB cases exists in communities, necessitating novel detection strategies.

Purpose of the Study:

  • To present the rationale, definitions, and key considerations for developing new World Health Organization (WHO) guidelines on systematic screening for active TB.
  • To explore the potential benefits and approaches for revisiting TB screening, including in high-risk groups and potentially community-wide screening.
  • To address the need for intensified efforts beyond access barriers and rapid diagnostics to find asymptomatic individuals with TB.

Main Methods:

  • Review of current TB detection trends and evidence from national TB prevalence surveys.
  • Analysis of existing World Health Organization (WHO) recommendations for TB screening in specific populations (e.g., HIV-infected, TB contacts).
  • Consideration of the potential role and methodologies for systematic screening in broader populations and community-wide settings.

Main Results:

  • Current TB case detection strategies appear to have reached their limit in effectiveness.
  • There is a substantial burden of undiagnosed TB in the community.
  • The effectiveness of intensified efforts and new diagnostics alone is uncertain, prompting a re-evaluation of screening approaches.

Conclusions:

  • Existing TB control measures may not be sufficient to accelerate progress towards elimination goals.
  • Systematic screening, potentially including previously discouraged methods like mass screening in specific contexts, warrants further investigation.
  • The WHO is actively developing new guidelines to address these challenges in active TB detection.