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Published on: April 9, 2014
Clinical profile of infants with hypsarrhythmia
1Queen Rania hospital for children, King Hussein medical center, Royal medical services, Amman. Jordan.
Insights
Infantile spasms in Jordan show similar patterns to developed countries, with a male predominance and common flexor seizures. Early developmental delay and birth asphyxia are significant associated factors.
Area of Science:
- Pediatric Neurology
- Developmental Neuroscience
Background:
- Infantile spasms (IS) are a severe form of epilepsy in infancy.
- Understanding the epidemiological profile of IS is crucial for early diagnosis and intervention.
Purpose of the Study:
- To establish a baseline profile of infantile spasms and associated neurological disorders in Jordan.
- To identify key demographic and clinical characteristics of IS patients.
Main Methods:
- A cohort of 50 patients with infantile spasms was studied at Queen Rania Hospital for Children.
- Data collected included demographics, seizure details, family history, perinatal factors, EEG, neuroimaging, and neurodevelopmental assessments.
Main Results:
- The mean age of onset was 4.8 months, with a male preponderance (74%). Flexor spasms were most common (52%).
- Developmental delay (52%) and birth asphyxia (48%) were frequent comorbidities. 78% of cases were classified as symptomatic.
Conclusions:
- The pattern of infantile spasms in Jordan aligns with international data.
- Preventive measures against birth asphyxia and further research are recommended to mitigate epilepsy and psychomotor retardation.
Objective:
The present study was done in order to obtain a baseline profile of infantile spasms and associated neurological disorders.
Patient And Methods:
The study included 50 patients with infantile spasm in Queen Rania Hospital for children in Jordan. The following data were obtained: sex, age at onset of spasms, details of seizure, family history of epilepsy, significant pre-/peri/ post-natal insults, Electroencephalography and detailed neuro imaging evaluation , detailed neurological, neuro developmental ,assessment were done by. Broad categories of possible etiologies were used the results were recorded for further study.
Results:
Age of onset of infantile spasms ranged from 1month to 1 year and 6 months , (mean 4.8 months). The mean time of presentation was 9.4 months . A male preponderance was noted (74 %). flexor spasms (52%) was the commonest . Other types of seizures also accompanied infantile spasm in 44% children . (84%) were born of normal delivery, History of birth asphyxia was obtained in 48%, 3 (6%) had positive family history Developmental delay was recognized prior to onset of spasms in 52%, microcephaly was the commonest associated problem, Imaging studies of the brain revealed abnormality in 18 patients. 78% patients were classified as symptomatic and 22 % as cryptogenic.
Conclusion:
the pattern of infantile spasm in our country do not differ from that of developed countries, further researches is required to prevent both chronic epilepsy and psychomotor retardation and .preventive measurement to prevent birth asphyxia is recommended.
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