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Cardiovascular autophagy: crossroads of pathology, pharmacology and toxicology

Joshua K Salabei1, Daniel J Conklin

  • 1Department of Medicine, Diabetes and Obesity Center, University of Louisville, 580 S. Preston Street, Delia Baxter Building, Rm. 404E, Louisville, KY, 40292, USA.

Cardiovascular Toxicology
|February 15, 2013
PubMed

Insights

Cardiovascular disease (CVD) treatments may be improved by understanding how FDA-approved drugs affect cellular autophagy. Harnessing drug-induced autophagy offers therapeutic potential for CVD management.

Area of Science:

  • Biomedical Science
  • Cellular Biology
  • Cardiovascular Medicine

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • Autophagy, a cellular recycling process, is implicated in various diseases, including CVD.
  • FDA-approved drugs can induce autophagy-related side effects in the cardiovascular system.

Purpose of the Study:

  • To review CVDs associated with autophagy.
  • To examine FDA-approved drugs with cardiovascular autophagy-mediated side effects.
  • To discuss the therapeutic potential of modulating autophagy for CVD.

Main Methods:

  • Literature review of cardiovascular diseases and autophagy.
  • Analysis of FDA-approved drugs and their impact on cardiovascular autophagy.
  • Exploration of small molecule modulators for autophagy in CVD management.

Main Results:

  • Autophagy is altered in numerous CVDs.
  • Certain FDA-approved drugs induce cardiovascular side effects via autophagy.
  • The role of autophagy in CVD can be adaptive or maladaptive.

Conclusions:

  • Drug-induced autophagy presents both challenges and opportunities for CVD treatment.
  • Careful consideration is needed to determine if autophagy modulation is beneficial.
  • Small molecule autophagy modulators show promise for managing CVD progression.

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