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Updated: May 14, 2026
11:28
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
Published on: March 25, 2016
Woringer-Kolopp disease mimicking foot dermatitis
1Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Cutis
|February 16, 2013
Summary
Woringer-Kolopp disease, a rare variant of mycosis fungoides, can mimic foot dermatitis. Successful treatment involved topical keratolytics and bexarotene gel, showing minimal lesions after 8 years.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Woringer-Kolopp disease (localized pagetoid reticulosis) is a rare, indolent cutaneous lymphoproliferative disorder.
- It is considered a solitary variant of mycosis fungoides (MF).
- Misdiagnosis can lead to prolonged symptoms and functional impairment.
Observation:
- A case of long-standing Woringer-Kolopp disease presented with symptoms mimicking foot dermatitis.
- Histopathology revealed epidermotropic infiltration of atypical lymphocytes (CD3+ CD4- CD8-).
Findings:
- The patient achieved successful treatment outcomes using topical keratolytics and bexarotene gel 1%.
- Minimal residual lesions were observed during an 8-year follow-up period.
Implications:
- This case highlights the importance of accurate diagnosis for Woringer-Kolopp disease to ensure appropriate management.
- Understanding its characteristics is crucial for differentiating it from localized MF and other epidermotropic T-cell lymphomas.
- Effective treatment strategies, including topical agents and bexarotene, can lead to long-term disease control.
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