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[Osteoporosis]
1Service des maladies osseuses, Département des spécialités de médecine, HUG et Faculté de medecine, 1211 Geneve 14. brigitte.uebelhart@hcuge.ch
Revue Medicale Suisse
|February 16, 2013
Summary
Type 2 diabetes increases fracture risk. While calcium supplements face cardiovascular concerns, vitamin D supplementation is recommended in Switzerland, and treatments like zoledronate and denosumab show promise in managing bone health and reducing fractures.
Area of Science:
- Bone metabolism and fracture risk.
- Endocrinology and metabolic disorders.
- Pharmacological interventions for bone health.
Context:
- Type 2 diabetes mellitus is linked to a higher incidence of fractures.
- Ongoing debate surrounds the cardiovascular safety of calcium supplements.
- Established Swiss guidelines exist for vitamin D supplementation.
- Long-term effects of bone resorption inhibitors are a key area of research.
Purpose:
- To review current understanding and evidence regarding bone health in the context of type 2 diabetes.
- To address the controversy surrounding calcium supplements and cardiovascular health.
- To highlight relevant vitamin D supplementation guidelines.
- To evaluate the long-term efficacy and safety of bone resorption inhibitors like zoledronate and denosumab.
Summary:
- Type 2 diabetes is a significant risk factor for fractures.
- The cardiovascular implications of calcium supplementation remain under investigation.
- Vitamin D supplementation is advised according to Swiss recommendations.
- Zoledronate demonstrates sustained inhibition of bone resorption.
- Denosumab treatment for 5 years is associated with low fracture incidence.
- Atypical femoral fractures linked to bisphosphonate therapy were assessed at the University Hospital of Geneva.
Impact:
- Informing clinical practice regarding fracture prevention in type 2 diabetes.
- Guiding decisions on calcium and vitamin D supplementation.
- Providing insights into the long-term management of bone health with antiresorptive agents.
- Contributing to the understanding of rare but serious side effects like atypical femoral fractures.
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