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Learning disabilities in Darier's disease patients
R Dodiuk-Gad1, M Lerner, Z Breznitz
1Department of Dermatology, Genetics Institute, Ha'emek Medical Center, Afula.
Journal of the European Academy of Dermatology and Venereology : JEADV
|February 16, 2013
Summary
This study found that 41% of Darier's disease patients have learning disabilities, a previously unreported association. Further investigation into personal and family history is recommended for early identification and support.
Area of Science:
- Dermatology
- Neuroscience
- Genetics
Background:
- Darier's disease is a rare genetic skin disorder.
- Neuropsychiatric issues and intellectual difficulties are known complications.
- Learning disabilities have not been systematically studied in Darier's disease patients.
Purpose of the Study:
- To determine the prevalence of learning disabilities in Darier's disease patients.
- To evaluate cognitive functioning in a subset of these patients.
Main Methods:
- A questionnaire was used to gather data on learning disabilities from 76 patients.
- Neuropsychological assessments were conducted on 19 patients to evaluate cognitive function.
- A control group of 42 skilled learners was used for comparison.
Main Results:
- 41% of patients reported learning disabilities, and 74% had a family history of them.
- Patients with Darier's disease showed significant differences in subtraction and multiplication tasks compared to controls.
- Reading difficulties were identified in 32% of evaluated patients, and 26% performed poorly on a concentration test.
- Overall cognitive ability remained within the average range for all patients.
Conclusions:
- This study suggests a novel association between Darier's disease and learning disabilities.
- It highlights the importance of inquiring about personal and family history of learning disabilities.
- Referral for further evaluation is advised for patients with clinical concerns.
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