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Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
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Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively manages...

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Intraportal Transplantation of Pancreatic Islets in Mouse Model
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Hyperglycemic management after solid organ transplantation.

Johnny L Rollins1

  • 1Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA. jlrollin@mdanderson.org

Critical Care Nursing Clinics of North America
|February 16, 2013
PubMed
Summary
This summary is machine-generated.

Hyperglycemia after organ transplantation poses risks like infection and graft loss. Effective blood glucose management can prevent new-onset diabetes post-transplant.

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Last Updated: May 14, 2026

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Published on: March 14, 2019

Area of Science:

  • Medicine
  • Transplantation
  • Endocrinology

Background:

  • Hyperglycemia is a common complication after solid organ transplantation.
  • Uncontrolled blood glucose elevates risks of infection, delayed healing, graft rejection, and graft loss.
  • It also increases the likelihood of developing new-onset diabetes mellitus in non-diabetic recipients.

Purpose of the Study:

  • To review current literature on blood glucose management in solid organ transplant recipients.
  • To discuss the challenges associated with hyperglycemia in this patient population.
  • To provide insights into effective strategies for managing hyperglycemia post-transplantation.

Main Methods:

  • Literature review of studies on hyperglycemia and blood glucose management in solid organ transplantation.
  • Analysis of the impact of hyperglycemia on transplant outcomes.
  • Discussion of current clinical guidelines and emerging strategies for glycemic control.

Main Results:

  • Hyperglycemia is linked to adverse outcomes including increased infection rates, impaired wound healing, and higher rates of graft rejection and loss.
  • Effective glycemic control is crucial for reducing the incidence of new-onset diabetes after transplantation (NODAT).
  • Management strategies require careful consideration of individual patient factors and transplant type.

Conclusions:

  • Controlling hyperglycemia is essential for improving outcomes in solid organ transplant recipients.
  • Proactive blood glucose management can mitigate risks and prevent the development of diabetes.
  • Further research into optimized management protocols is warranted.