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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

Hypothermia for aortic surgery.

Randall B Griepp¹, Gabriele Di Luozzo

¹Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY, USA. randall.griepp@mountsinai.org

The Journal of Thoracic and Cardiovascular Surgery

|February 16, 2013

Summary

This summary is machine-generated.

Deep hypothermia during circulatory arrest offers acceptable neurologic outcomes for aortic arch repairs. Studies in pigs and patients support its routine use for organ protection in complex aortic surgeries.

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Area of Science:

Cardiovascular Surgery
Neurology
Organ Preservation

Background:

Hypothermic circulatory arrest (HCA) is employed in aortic arch repairs.
Previous research has investigated the impact of deep hypothermia on brain metabolism and perfusion.
HCA is also utilized for organ protection during thoracoabdominal aortic aneurysm repair.

Purpose of the Study:

To review and synthesize clinical and laboratory evidence supporting the use of HCA.
To advocate for the routine application of HCA in surgical practice.

Main Methods:

Review of existing clinical studies on HCA in aortic surgery.
Analysis of laboratory investigations examining brain metabolism and perfusion under hypothermia.
Evaluation of outcomes in patients undergoing aortic arch and thoracoabdominal aneurysm repair with HCA.

Main Results:

Acceptable neurologic outcomes have been observed with HCA during aortic arch repairs.
Deep hypothermia demonstrates specific effects on brain metabolism and perfusion.
HCA serves as an effective organ protection strategy in complex aortic aneurysm repair.

Conclusions:

The evidence supports the routine use of hypothermic circulatory arrest in clinical practice.
HCA is a valuable technique for achieving acceptable neurologic outcomes and organ protection in major aortic surgeries.