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Updated: May 14, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Pediatric retinal conditions imaged by ultra wide field fluorescein angiography
Irena Tsui1, Valentina Franco-Cardenas, Jean-Pierre Hubschman
1Jules Stein Eye Institute, University of California, Los Angeles, California, USA. itsui@jsei.ucla.edu
Insights
Ultra wide field fluorescein angiography (UWFFA) successfully imaged the macula and periphery in children. This diagnostic tool provided crucial information for managing pediatric eye conditions.
Area of Science:
- Ophthalmology
- Pediatric Imaging
- Diagnostic Angiography
Background:
- Ultra-wide field imaging technology was initially developed for pediatric applications.
- Assessing the utility of ultra-wide field fluorescein angiography (UWFFA) in pediatric patients is crucial for advancing eye care.
Purpose of the Study:
- To evaluate the efficacy and diagnostic yield of ultra-wide field fluorescein angiography (UWFFA) in children.
- To assess the quality of UWFFA imaging in a pediatric cohort.
Main Methods:
- Retrospective case series involving pediatric patients under 13 years of age who underwent UWFFA.
- Analysis of angiographic findings, diagnostic impact, management influence, and image quality (field of view, phases, artifacts).
Main Results:
- Peripheral findings like vasculitis, telangiectasia, and neovascularization were identified in 75% of patients.
- Adequate imaging of the macula and periphery was achieved, with venous and recirculation phases captured in all patients.
Conclusions:
- Ultra-wide field fluorescein angiography (UWFFA) is a feasible and effective imaging modality in pediatric ophthalmology.
- UWFFA provides valuable diagnostic and management information, including visualization of peripheral retinal abnormalities.
Background And Objective:
Ultra wide field technology was originally designed for use in children. The purpose of this study was to evaluate ultra wide field fluorescein angiography (UWFFA) in children.
Patients And Methods:
Retrospective case series of patients younger than 13 years who underwent UWFFA. Angiographic findings and their impact on diagnosis and management were assessed. UWFFA quality was evaluated, including phases of the angiogram available in each study, field of view, and artifacts.
Results:
Forty images of 16 patients with a mean age of 9.3 years were included. Peripheral angiographic findings such as vasculitis, telangiectasia, and neovascularization were present in 12 of 16 patients (75%). Seven of 16 patients (43.8%) had images during the arterial phase, and 16 of 16 patients (100%) had venous and recirculation phases captured.
Conclusion:
UWFFA was successfully performed in this group of children. The macula and periphery were adequately imaged, obtaining important information for documentation, diagnosis, and management.
