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Study on the clinical significance of Argonaute2 expression in colonic carcinoma by tissue microarray
Ying-Xin Wang1, Xiao-Yan Zhang, Bao-Feng Zhang
1Department of Gastroenterology, Tongji University Shanghai, China.
Background:
To study the expression levels and clinical significance of Argonaute2 (EIF2C2) on colonic carcinomas and normal tissues.
Methods:
Colon tissue samples from 90 cases of colonic carcinomas and 90 normal subjects were accumulated and made into a tissue microarray containing 360 dots. Expression of Argonaute2 (EIF2C2) was detected by immunohistochemical staining of the tissue microarray.
Results:
There was significant difference in the expression levels of Argonaute2 (EIF2C2) between colonic carcinomas and normal tissues (P<0.01). However, the expression of Argonaute2 (EIF2C2) was not related to sex, age, position, differentiation, lymphatic metastasis and clinical stage of the tumor (P>0.05).
Conclusion:
Abnormal expression of Argonaute2 (EIF2C2) may be correlated with colon tumorigenesis.
