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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

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Published on: August 28, 2020

Management of refractory overactive bladder.

I Giarenis1, L Cardozo

  • 1Department of Urogynecology, King's College Hospital NHS Foundation Trust, London, UK. ilias.giarenis@nhs.net

Minerva Ginecologica
|February 16, 2013
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) is a common condition impacting well-being. This review explores management strategies for refractory OAB in women, focusing on advanced treatments beyond initial therapies.

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Area of Science:

  • Urology
  • Gynecology
  • Geriatrics

Background:

  • Overactive bladder (OAB) is a prevalent syndrome characterized by urgency, frequency, and nocturia, often impacting quality of life.
  • Despite initial treatments like behavioral therapy and antimuscarinic agents, approximately 40% of patients experience refractory symptoms.
  • Underdiagnosis and undertreatment contribute to the significant physical and psychological burden of OAB.

Purpose of the Study:

  • To review and outline management strategies for women with refractory overactive bladder (OAB) who have not responded to conservative therapies.
  • To provide a comprehensive overview of treatment options for persistent OAB symptoms.
  • To guide clinicians in managing challenging OAB cases.

Main Methods:

  • Literature review focusing on refractory overactive bladder (OAB) management in women.
  • Analysis of treatment modalities beyond initial conservative approaches.
  • Discussion of advanced pharmacological and procedural interventions.

Main Results:

  • Persistent OAB necessitates thorough clinical assessment and investigation of underlying pathologies.
  • Treatment escalation may involve bladder-selective antimuscarinics, alternative formulations, or different drug classes.
  • Advanced options include intravesical Botulinum toxin, neuromodulation, and, as a last resort, reconstructive surgery or catheterization.

Conclusions:

  • Refractory overactive bladder (OAB) in women requires a systematic approach to treatment escalation.
  • A range of advanced therapies are available for patients unresponsive to initial management.
  • Careful patient selection and consideration of all therapeutic options are crucial for optimizing outcomes in refractory OAB.