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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: May 14, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic sclerosis: genetics and epigenetics.

Yangyang Luo1, Yaoyao Wang, Qing Wang

  • 1Department of Dermatology, Second Xiangya Hospital, Central South University, #139 Renmin Middle Road, Changsha, Hunan 410011, China.

Journal of Autoimmunity
|February 19, 2013
PubMed
Summary
This summary is machine-generated.

Genetic and epigenetic factors contribute to systemic sclerosis (SSc), an autoimmune disease. Research highlights susceptibility genes and epigenetic changes like DNA demethylation and microRNA alterations in SSc pathogenesis.

Related Experiment Videos

Last Updated: May 14, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Immunology
  • Genetics
  • Epigenetics

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease with unknown etiology.
  • Characterized by immune dysfunction, vascular damage, and fibrosis.
  • Recent research explores genetic and environmental factors in SSc pathogenesis.

Purpose of the Study:

  • To review recent advances in understanding the genetic and epigenetic basis of Systemic Sclerosis.
  • To highlight key findings from genome-wide association studies (GWAS) and epigenetic research.

Main Methods:

  • Review of literature on genetic susceptibility in SSc.
  • Analysis of genome-wide association studies (GWAS) identifying HLA and non-HLA genes.
  • Examination of epigenetic modifications, including DNA demethylation and microRNA expression.

Main Results:

  • Identified HLA genes (HLA-A, -B, -C, -DR, -DP, -DQ) and numerous non-HLA genes associated with SSc susceptibility.
  • Different genetic variants correlate with specific clinical patterns in SSc.
  • Observed DNA demethylation in regulatory genes (e.g., eNOS, CD40L, CD70) and altered microRNA expression (e.g., miR-21, -31, -146) in SSc patients.

Conclusions:

  • Both genetic and epigenetic aberrations are crucial in the development of Systemic Sclerosis.
  • Further research is needed to identify biomarkers for early diagnosis and prognosis to improve patient outcomes.