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Related Experiment Video

Updated: May 14, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

The altered gut microbiome and necrotizing enterocolitis.

Roberto Murgas Torrazza¹, Josef Neu

¹Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, 1600 Southwest Archer Road, Box 100296, HD Building Room 112, Gainesville, FL 32610-0296, USA.

Clinics in Perinatology

|February 19, 2013

Summary

Developing a healthy intestinal microbiota is crucial for neonates, particularly preterm infants. Medical interventions can significantly impact this delicate gut flora, influencing long-term infant health outcomes.

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Last Updated: May 14, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

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Published on: July 28, 2023

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Area of Science:

Neonatal health
Microbiology
Pediatric medicine

Background:

The intestinal microbiota plays a vital role in infant health and development.
Maintaining the homeostasis of the gut microbiota is essential for preventing disease.
Neonatal care, especially for preterm infants, can disrupt the delicate balance of the intestinal flora.

Purpose of the Study:

To emphasize the critical role of a healthy intestinal microbiota in neonates.
To highlight the potential impact of medical interventions on neonatal gut flora.
To underscore the need for improved understanding and management of intestinal microbiota in infants.

Main Methods:

Review of current evidence on neonatal intestinal microbiota.
Analysis of factors influencing gut microbiota homeostasis in infants.
Discussion of the impact of medical interventions on neonatal gut flora.

Main Results:

Evidence strongly supports the importance of a healthy intestinal microbiota for neonatal health.
The equilibrium of the intestinal microbiota is sensitive to medical interventions in neonates.
Preterm infants are particularly vulnerable to disruptions in their gut flora.

Conclusions:

Developing and maintaining a healthy intestinal microbiota is paramount for long-term infant well-being.
Physician interventions require careful consideration due to their potential to alter neonatal gut flora.
Advancements in molecular techniques will enable more effective, long-lasting interventions for infant gut health.