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Updated: May 14, 2026
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Towards more effective advanced drug delivery systems
Daan J A Crommelin1, Alexander T Florence
1Department of Pharmaceutical Sciences, University of Utrecht, 3511 ME Utrecht, The Netherlands. d.j.a.crommelin@uu.nl
International Journal of Pharmaceutics
|February 19, 2013
Summary
Advanced drug delivery systems, especially nanomedicines, require standardized characterization and in vivo/in vitro data. Focusing on effective drug levels in target organs is crucial for clinical translation.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Nanomedicine
Background:
- Review of advanced drug delivery systems (nanometre domain) based on international expert discussions.
- Addresses nomenclature, nanotechnology claims, in vivo targeting, and in vitro study standards.
- Highlights historical development and the stochastic nature of drug delivery processes.
Framework:
- Need for standardized characterization of nanocarriers and cell lines for in vitro/in vivo studies.
- Emphasis on manufacturability, stability, analytical profiling, and toxicology of drug delivery systems.
- Identifies a data gap in comparing carrier systems across standardized in vitro and in vivo models.
Implementation:
- Proposes increased focus on achieving effective drug concentrations within target organs.
- Recommends using diagnostic/imaging technologies for monitoring targeted delivery and patient stratification.
- Advocates for data generation to facilitate clinical translation of experimental systems.
Implications:
- Clinical translation of advanced drug delivery systems hinges on robust efficacy data and targeted delivery.
- Integration of imaging technologies will enable personalized therapy and patient selection.
- Development of science-based regulatory policies, oversight platforms, and novel financing models is essential.
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