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Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
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A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by

Adam B Shapiro1

  • 1Bioscience Department, Infection Innovative Medicines, AstraZeneca R&D Boston, Waltham, MA 02451 USA. adam.shapiro@astrazeneca.com

Biochemical Pharmacology
|February 19, 2013
PubMed

Keywords:
DNA relaxationdrug screeningbiochemical assayenzyme kinetics

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