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Related Experiment Video

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Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

Tremor suppression by rhythmic transcranial current stimulation.

John-Stuart Brittain1, Penny Probert-Smith, Tipu Z Aziz

  • 1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Current Biology : CB
|February 19, 2013
PubMed
Summary
This summary is machine-generated.

Noninvasive transcranial alternating current stimulation (TACS) offers a new way to reduce Parkinson's disease tremor. This technique uses targeted electrical stimulation to cancel tremor rhythms, achieving significant amplitude reduction without surgery.

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Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Engineering

Background:

  • Parkinson's disease tremor is debilitating and poorly managed by medication.
  • Deep brain stimulation offers tremor relief but carries risks like hemorrhage.
  • Current treatments for Parkinson's disease tremor are limited in efficacy and safety.

Purpose of the Study:

  • To pioneer a noninvasive method for tremor suppression using transcranial alternating current stimulation (TACS).
  • To investigate the phase cancellation of cortical oscillations underlying rest tremor.
  • To establish a foundation for closed-loop tremor-suppression therapy.

Main Methods:

  • Noninvasive transcranial alternating current stimulation (TACS) applied over the motor cortex.
  • Identification of tremor-related cortical oscillation timing through phase alignment drift.
  • Delivery of TACS at identified phase alignments to induce tremor suppression.

Main Results:

  • Achieved almost 50% average reduction in resting tremor amplitude.
  • Demonstrated controlled suppression of ongoing tremor via phase cancellation.
  • Identified specific phase alignments for maximal tremor amplitude modulation.

Conclusions:

  • TACS provides a noninvasive alternative for significant tremor reduction in Parkinson's disease.
  • Phase cancellation of cortical oscillations is a viable mechanism for tremor suppression.
  • This technique forms the basis for a potential closed-loop tremor-suppression therapy for oscillopathies.