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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
Republished: drug-induced valvular heart disease
Bernard Cosyns1, Steven Droogmans, Raphael Rosenhek
1CHIREC, Department of Cardiology, UZ Brussel, Brussels, Belgium. bcosyns@gmail.com
Postgraduate Medical Journal
|February 19, 2013
Summary
Drug-induced valvular heart disease (DIVHD) can result from various medications, even years after stopping treatment. Early recognition of clinical and echocardiographic risk factors is crucial for timely management of this severe condition.
Area of Science:
- Cardiology
- Pharmacology
- Toxicology
Background:
- Drug-induced valvular heart disease (DIVHD) has been recognized since the 1960s.
- Associations include ergot derivatives, anorectic drugs, Parkinson's treatments, hyperprolactinemia medications, MDMA, and benfluorex.
- DIVHD can manifest years after drug cessation, necessitating long-term patient monitoring.
Purpose of the Study:
- To review the associations between various drugs and valvular heart disease.
- To highlight the potential for severe and persistent DIVHD.
- To emphasize the importance of early recognition and management.
Main Methods:
- Literature review of reported cases and associations.
- Analysis of historical and recent drug-induced valvular heart disease findings.
- Synthesis of clinical and echocardiographic risk factors.
Main Results:
- DIVHD is associated with a wide range of medications.
- The condition can be severe and may require surgical intervention.
- Long-term sequelae of DIVHD can persist even after drug discontinuation.
Conclusions:
- DIVHD is a significant clinical concern with diverse etiologies.
- Prompt identification of risk factors and early diagnosis are essential.
- Effective management strategies are needed to address the long-term implications of DIVHD.
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