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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: May 14, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Nodular regenerative hyperplasia in common variable immunodeficiency.

Ivan J Fuss1, Julia Friend, Zhiqiong Yang

  • 1Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ifuss@niaid.nih.gov

Journal of Clinical Immunology
|February 20, 2013
PubMed
Summary
This summary is machine-generated.

Nodular regenerative hyperplasia (NRH) is a serious liver complication in Common Variable Immunodeficiency (CVID) patients, potentially leading to severe outcomes including death. Early detection and intervention are crucial for managing this CVID-associated liver disease.

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Related Experiment Videos

Last Updated: May 14, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Area of Science:

  • Immunology
  • Hepatology
  • Gastroenterology

Background:

  • Common Variable Immunodeficiency (CVID) patients are at risk for developing liver disease.
  • Nodular regenerative hyperplasia (NRH) is a recognized but poorly understood complication in CVID.
  • This study aimed to characterize NRH in CVID patients.

Purpose of the Study:

  • To define the clinical characteristics of NRH in CVID patients.
  • To investigate the natural course and outcomes of NRH in this population.
  • To explore potential autoimmune mechanisms underlying NRH in CVID.

Main Methods:

  • Retrospective and prospective review of CVID patient clinical courses.
  • Analysis of liver biopsy specimens for NRH and cytokine profiles (RT-PCR).
  • Evaluation of immunologic markers, including T cell-derived IFN-γ.

Main Results:

  • NRH occurred in approximately 5% of CVID patients studied.
  • Common initial presentation: elevated alkaline phosphatase.
  • Progressive disease observed: portal hypertension, hypersplenism, neutropenia, thrombocytopenia, ascites.
  • Significant subset developed autoimmune hepatitis-like (AIH-like) disease, often fatal.
  • Histology showed NRH with interface hepatitis and fibrosis; T cells producing IFN-γ suggested autoimmunity.

Conclusions:

  • NRH in CVID is not always benign and can be severe.
  • NRH can be a potentially fatal complication of CVID.
  • Close monitoring and timely intervention are essential for CVID patients with NRH.