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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

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Related Experiment Video

Updated: May 14, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Hematopoietic stem cell donation.

Shu-Huey Chen1, Tso-Fu Wang, Kuo-Liang Yang

  • 1Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.

International Journal of Hematology
|February 20, 2013
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cell donation via bone marrow or peripheral blood is generally safe for healthy donors, with mostly transient side effects. Current evidence does not link donation to increased risks of marrow failure or cancer.

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Last Updated: May 14, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Area of Science:

  • Hematology
  • Transplantation Medicine
  • Medical Ethics

Background:

  • Allogeneic hematopoietic stem cell transplantation is a crucial therapy for various diseases.
  • Hematopoietic stem cell donation, through bone marrow (BM) or peripheral blood stem cell (PBSC) collection, is a standard procedure.

Purpose of the Study:

  • To review the safety and potential complications associated with hematopoietic stem cell donation.
  • To emphasize the importance of donor evaluation, informed consent, and risk assessment.

Main Methods:

  • Review of established procedures for bone marrow harvesting and peripheral blood stem cell collection.
  • Analysis of common and severe adverse events reported in stem cell donors.
  • Examination of current evidence regarding long-term risks for donors.

Main Results:

  • Bone marrow and PBSC collection procedures have generally well-tolerated, transient side effects like pain and fatigue.
  • Severe adverse events in healthy donors are infrequent.
  • No definitive evidence links stem cell donation to increased risks of marrow failure or cancer.

Conclusions:

  • Stem cell donation is a safe procedure for healthy donors, with manageable risks.
  • Thorough donor evaluation, informed consent, and screening for infections are critical.
  • Understanding potential complications is essential for maintaining physician confidence in this practice.