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Essential thrombocythemia in a cat.

A S Hammer1, C G Couto, D Getzy

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus.

Journal of Veterinary Internal Medicine
|March 1, 1990
PubMed
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Diagnosis of essential thrombocythemia in a cat was achieved using human criteria. Despite meeting diagnostic standards, the cat did not respond to treatment and succumbed to sepsis, highlighting challenges in feline hematologic disorders.

Area of Science:

  • Veterinary Hematology
  • Feline Medicine
  • Oncology

Background:

  • Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts.
  • Diagnostic criteria for ET are well-established in humans but less defined in feline patients.
  • This case explores the application of human diagnostic criteria for ET in a feline subject.

Observation:

  • A cat presented with a persistently elevated platelet count (>600,000/microL).
  • The cat met all five applicable diagnostic criteria for ET established by the Polycythemia Vera Study Group.
  • Normal thrombopoietin levels and splenic hypofunction were also noted.

Findings:

  • The feline patient was diagnosed with essential thrombocythemia based on established human criteria.

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  • Treatment with melphalan, a chemotherapeutic agent, failed to reduce the platelet count.
  • The cat ultimately died due to sepsis.

    • Implications:

    • This case demonstrates the feasibility of applying human ET diagnostic criteria to cats.
    • It highlights the potential for poor prognosis and treatment challenges in feline ET.
    • Further research is needed to establish specific feline diagnostic and therapeutic guidelines for myeloproliferative neoplasms.