Research of the incubation and hybridization instrument with vibration for nanoparticles

Nanoparticles are the largest and most widely used nanomaterial in biomedical research nowadays, which are always used in solution. However, traditional techniques, such as hybridization oven are not appropriate for the incubation and hybridization of nanoparticles. Thus designing and developing an effective method and instrument for hybridization of nanoparticles is very essential to solve these present problems. This paper introduced and successfully designed a hybridization instrument, including insulated and closed chamber, temperature control system, motion control system input and output control system. The instrument can not only control temperature precisely to meet various requirements for chemical and biological molecule's incubation and hybridization on nanomaterials, but also make liquid flow slowly and shake according to a certain frequency for mixing to improve hybridization efficiency significantly. The control algorithm of temperature applied PID and fuzzy-PID, the accuracy is improved and stable. Vibration is the most obvious and advantageous feature of the instrument. Furthermore the core control system was improved whose core is C8051F060 MCU and designed into panel.