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A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
Skin tolerance is supported by the spleen
M Buettner1, M Bornemann, U Bode
1Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Buettner.Manuela@MH-Hannover.de
Scandinavian Journal of Immunology
|February 21, 2013
Summary
Repeated antigen exposure induces immune tolerance, with lymph nodes producing suppressor cells. The spleen plays a role in peripheral tolerance, influencing delayed-type hypersensitivity (DTH) responses and immune cell populations.
Area of Science:
- Immunology
- Cell Biology
Background:
- Repeated antigen administration induces immune tolerance.
- Lymph nodes produce suppressor cells, mediating tolerogenic phenotypes.
- Stromal cells from different lymph nodes induce distinct suppressor cell populations.
Purpose of the Study:
- To investigate the spleen's role in immune tolerance induction.
- To compare tolerance mechanisms in control versus splenectomized mice.
- To analyze the impact of spleen removal on delayed-type hypersensitivity (DTH) and immune cell composition.
Main Methods:
- Induction of tolerance through oral or injected ovalbumin in control and splenectomized mice.
- Measurement of delayed-type hypersensitivity (DTH) response.
- Analysis of spleen cell subset composition and antibody production.
Main Results:
- The spleen in peripherally tolerized mice exhibited increased proliferation and specific antibody production compared to orally tolerized mice, which showed predominant regulatory T cells.
- Spleen removal reduced DTH responses in antigen-fed mice.
- Skin tolerance induction was impaired in splenectomized mice.
Conclusions:
- Lymph nodes utilize distinct pathways for immune tolerance.
- The spleen is integral to peripheral tolerance induction.
- Spleen removal significantly impacts DTH responses and tolerance mechanisms.
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