Related Experiment Video
Updated: May 14, 2026
09:38
Single-throughput Complementary High-resolution Analytical Techniques for Characterizing Complex Natural Organic Matter Mixtures
Published on: January 7, 2019
Toward personalized nutrition: comprehensive phytoprofiling and metabotyping
Guoxiang Xie1, Xin Li, Houkai Li
1Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai 200233, China.
Journal of Proteome Research
|February 21, 2013
Summary
Personalized nutrition research uses metabolic phenotyping and phytochemical profiling to understand how diet impacts health. These methods help discover biomarkers for tailored nutritional interventions and health benefits.
Area of Science:
- Nutritional Science
- Metabolomics
- Personalized Medicine
Background:
- Nutrition research faces challenges due to complex dietary interactions and individual metabolic variability.
- Understanding nutrient effects requires integrating genetic, microbial, environmental, and dietary factors.
- Metabonomics offers a powerful approach to assess metabolic responses to nutritional variations.
Purpose of the Study:
- To provide an overview of metabolic phenotyping and phytochemical profiling in personalized nutrition.
- To highlight recent advances in understanding phytochemicals' role in metabolic regulation.
- To emphasize the discovery of novel biomarkers for nutritional requirements and interventions.
Main Methods:
- Metabolic phenotyping (metabotyping) to characterize individual metabolic phenotypes.
- Phytochemical profiling (phytoprofiling) to measure dietary plant compounds.
- Integration of genetic, gut microbiota, and environmental factors into metabolic analysis.
Main Results:
- Metabotyping and phytoprofiling facilitate the measurement of key health determinants.
- These profiling strategies aid in discovering biomarkers for nutritional needs.
- Advances focus on phytochemicals' impact on human and animal metabolic systems.
Conclusions:
- Metabolic phenotyping and phytochemical profiling are crucial for personalized nutrition research.
- These approaches enhance the substantiation of nutritional health benefits.
- Future research will leverage these methods to optimize health through tailored dietary strategies.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
01:27Pharmacogenetics of Drug Metabolism: Overview
Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
01:33Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...