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Updated: May 14, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Maternal depression and the intergenerational transmission of relational impairment
Shaina J Katz1, Constance L Hammen, Patricia A Brennan
1Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095-1563, USA. sjkatz@ucla.edu
Abstract:
Previous research has demonstrated that the offspring of depressed mothers are at greater risk for negative psychopathological and psychosocial outcomes than children of nondepressed mothers. This study specifically examines offspring's romantic relationship quality during the transition to adulthood as a function of maternal depression and 3 putative mechanisms for this association: youth depression history, mother-child relationship discord, and maternal romantic relationship difficulties. The study further explores the role of these factors in the risk for depressive symptoms during the transition to adulthood. Hypotheses were examined longitudinally in a community sample of 182 Australian youth who were followed from birth to age 20 and were in committed romantic relationships at age 20 with romantic partners willing to provide data regarding romantic relationship satisfaction. Structural equation modeling analyses found support for a direct effect of maternal depression on youth romantic relationship quality with significant mediation by mother-child relationship discord, as well as an association between mother-child relationship discord and later depressive symptoms that is mediated by youth romantic relationship quality. Findings also lend support for an indirect effect of maternal depression on youth depressive symptoms via mother-child relationship discord and youth romantic relationship quality. This study provides further evidence for the negative psychosocial and psychopathological outcomes of children of depressed mothers and the intergenerational transmission of relational difficulties.
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