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Related Experiment Video

Updated: May 14, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels
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Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Switchable catalytic acrylamide hydrogels cross-linked by hemin/G-quadruplexes.

Chun-Hua Lu1, Xiu-Juan Qi, Ron Orbach

  • 1Institute of Chemistry, The Hebrew University of Jerusalem and The Center for Nanoscience and Nanotechnology, Jerusalem 91904, Israel.

Nano Letters
|February 21, 2013
PubMed
Summary

This study presents a novel hydrogel formed by G-quadruplex cross-linking of acrylamide copolymers. The hydrogel

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Area of Science:

  • Polymer Chemistry
  • Supramolecular Chemistry
  • Biomaterials Science

Background:

  • Guanine (G)-rich oligonucleotides can form G-quadruplex structures.
  • Hydrogels are cross-linked polymer networks with high water content.
  • Stimuli-responsive materials offer tunable properties for advanced applications.

Purpose of the Study:

  • To develop a novel hydrogel using G-quadruplex cross-linking.
  • To investigate the reversible formation and dissociation of the hydrogel.
  • To create a catalytic hydrogel mimicking horseradish peroxidase activity.

Main Methods:

  • Synthesis of acrylamide copolymers with guanine-containing oligonucleotide tethers.
  • Induction of hydrogel formation using potassium (K(+)) ions.

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  • Dissociation of the hydrogel using 18-crown-6 ether.
  • Characterization using rheology, circular dichroism, and spectroscopic methods.
  • Evaluation of catalytic activity in the presence of hemin.

    • Main Results:

    • A hydrogel was successfully formed via K(+)-induced G-quadruplex cross-linking.
    • The hydrogel exhibited reversible formation and dissociation upon cyclic addition of K(+) ions and 18-crown-6 ether.
    • The hemin/G-quadruplex-cross-linked hydrogel demonstrated horseradish peroxidase-like catalytic activity.
    • Catalytic functions could be cyclically activated and deactivated.

    Conclusions:

    • A novel, stimuli-responsive hydrogel based on G-quadruplex cross-linking was developed.
    • The hydrogel's reversible nature allows for controlled formation and dissociation.
    • The catalytic hydrogel shows potential for applications mimicking enzymatic functions.