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Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms

Gordon Ramage1, Anto Jose, Leighann Sherry

  • 1Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. gordon.ramage@glasgow.ac.uk

Antimicrobial Agents and Chemotherapy
|February 21, 2013
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...