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Related Concept Videos

Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

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Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Related Experiment Videos

A proof-of-concept study: mirabegron, a new therapy for overactive bladder.

Christopher R Chapple1, Gerard Amarenco, Miguel A López Aramburu

  • 1Department of Urology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.

Neurourology and Urodynamics
|February 21, 2013
PubMed
Summary
This summary is machine-generated.

Mirabegron effectively reduced overactive bladder (OAB) symptoms, significantly improving micturition frequency compared to placebo. This study establishes mirabegron as a well-tolerated, novel oral therapy for OAB.

Keywords:
overactive bladderphase 2 studyβ3-adrenoceptor agonist

Related Experiment Videos

Area of Science:

  • Pharmacology
  • Urology
  • Clinical Trials

Background:

  • Overactive bladder (OAB) significantly impacts quality of life.
  • Existing OAB treatments have limitations.
  • Novel therapeutic targets for OAB are needed.

Purpose of the Study:

  • To assess the efficacy and safety of mirabegron, a selective β3-adrenoceptor agonist, for OAB symptom treatment.
  • To establish mirabegron as a potential new oral pharmacological therapy for OAB.

Main Methods:

  • A Phase 2, multicenter, randomized, double-blind, placebo-controlled study.
  • 314 patients with OAB received mirabegron (100 or 150 mg twice-daily), placebo, or tolterodine ER (4 mg once-daily) for 4 weeks.
  • Primary endpoint: change in micturition frequency; secondary endpoints: incontinence, urgency, quality of life.

Main Results:

  • Mirabegron (100 and 150 mg BID) significantly reduced micturition frequency compared to placebo (P ≤ 0.01).
  • Statistically significant improvements were observed for most secondary endpoints, including quality of life.
  • Mirabegron demonstrated good safety and tolerability, with a minor increase in pulse rate.

Conclusions:

  • Mirabegron is an efficacious and well-tolerated treatment for overactive bladder symptoms.
  • Mirabegron represents a new class of oral pharmacological therapy for OAB, the first in over 30 years.