Related Experiment Video
Updated: May 14, 2026
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
Enhanced payload of lipid nanocarriers using supersaturated solution prepared by solvent-mediated method
H M Nguyen1, I C Hwang, D K Kweon
1School of Life Sciences and Biotechnology, Korea University , Seoul , South Korea.
Journal of Microencapsulation
|February 22, 2013
Summary
Researchers developed supersaturated deltamethrin (SSD) solutions to enhance lipid nanocarrier payloads. This solvent-mediated method significantly increased deltamethrin loading in nanocarriers compared to traditional methods.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmacology
Background:
- Enhancing the payload of nanocarriers is crucial for improving drug delivery efficacy.
- Traditional methods for preparing supersaturated solutions can be inefficient for certain active ingredients like deltamethrin.
Purpose of the Study:
- To develop an effective method for preparing supersaturated deltamethrin (SSD) solutions.
- To produce lipid nanocarriers with enhanced payload using the prepared SSD solution.
- To evaluate the impact of the solvent-mediated method on nanocarrier payload and encapsulation efficiency.
Main Methods:
- Preparation of supersaturated deltamethrin (SSD) solution via a solvent-mediated method.
- Production of lipid nanocarriers using a combination of homogenization and sonication.
- Characterization of deltamethrin solubility and nanocarrier payload and encapsulation efficiency.
Main Results:
- The solvent-mediated method yielded an SSD solution with 3.4 times higher deltamethrin solubility than saturated deltamethrin (SD) solution.
- Lipid nanocarriers produced from SSD exhibited significantly enhanced payloads (2.1x and 4.4x higher than SSD from thermal-mediated and SD methods, respectively).
- High encapsulation efficiency was maintained despite the increased payload.
Conclusions:
- The solvent-mediated method is highly effective for preparing supersaturated deltamethrin solutions, boosting solubility.
- This approach significantly enhances the payload of lipid nanocarriers without compromising encapsulation efficiency.
- The developed method offers a promising strategy for improving the loading capacity of nanocarriers for active ingredients.
More Related Videos
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
01:16Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...