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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Related Experiment Video

Updated: May 14, 2026

Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners
10:48

Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners

Published on: October 25, 2024

When do we transfuse cryoprecipitate?

M A Anderson1, B Glazebrook, B Cutts

  • 1Transfusion Medicine, Australian Red Cross Blood Service, Melbourne, Victoria, Australia.

Internal Medicine Journal
|February 22, 2013
PubMed
Summary
This summary is machine-generated.

Current clinical practice for cryoprecipitate transfusion shows significant variation from established guidelines. This audit highlights discrepancies, informing updated transfusion guidelines and clinician education for safer patient blood management.

Keywords:
auditcryoprecipitatefibrinogenguidelinetransfusion

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Last Updated: May 14, 2026

Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners
10:48

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Transfusion Medicine
  • Clinical Audit
  • Patient Blood Management

Background:

  • Current clinical practice guidelines for cryoprecipitate are undergoing revision.
  • Cryoprecipitate is now integrated into new Patient Blood Management modules.
  • Understanding current usage patterns is crucial for guideline relevance.

Purpose of the Study:

  • To audit current cryoprecipitate use in Victoria, Tasmania, and ACT.
  • To assess adherence to existing transfusion guidelines.
  • To identify deviations and inform future guideline development and clinician education.

Main Methods:

  • A clinical audit of consecutive cryoprecipitate transfusion episodes was conducted.
  • Data were collected over an 11-month period in 2008 using a standardized pro forma.
  • Electronic collation and algorithmic analysis determined guideline alignment.

Main Results:

  • Surgery represented the largest volume of cryoprecipitate use.
  • Guideline alignment was 26%, increasing to 61% with a modified fibrinogen trigger.
  • Fibrinogen levels alone did not always dictate transfusion decisions, with bleeding risk and empiric use noted.

Conclusions:

  • Significant discrepancies exist between current cryoprecipitate transfusion practices and guidelines.
  • These findings provide a rationale for updating existing transfusion guidelines.
  • Restricting cryoprecipitate use to evidence-based scenarios is recommended due to associated risks.